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Geological Society, London, Special Publications; 1996; v. 113; p. 231-237;
DOI: 10.1144/GSL.SP.1996.113.01.19
© 1996 Geological Society of London

The protective role of trace elements in preventing aflatoxin induced damage: a review

M. G. Nair, S. M. Maxwell & B. J. Brabin

Tropical Child Health Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK

Recent evidence has shown that there are important interactions in experimental models and human beings between trace element status and aflatoxin B1 (AFB1) exposure. The hypothesis is presented that these interactions operate through altered host antioxidant status leading to excess free radical production resulting in cell damage and clinical disease. Geographical differences in the geochemical environment could have a major influence on the pattern of disease. Appropriate nutritional intervention studies are required to determine potential benefits of trace element supplementation in aflatoxin exposed populations.